Continued high morbidity and complications due to trauma related hemorrhage underscores the importance of efforts to fully understand the temporal progression of molecular physiologic events needed to bring life-saving changes to practice. The current state of trauma diagnostics emphasizes vital signs and stat metabolic biomarkers. Tachycardia and hypotension are markers of hemorrhagic shock in decompensated trauma patients. Base deficit has been predicative of injury severity at hospital admission. Tissue oxygen saturation has been predicative of onset of multiple organ dysfunction syndrome (MODS). Blood potassium levels increase with onset of hemorrhagic shock. Lactate is a surrogate for tissue hypoxia and its clearance predicts mortality. Insulin resistance and attendant triage glucose measurements have been shown to be specific in predicting major injuries. No vital sign has yet to be proven effective as an independent predictor of trauma severity. Implantable point-of-care (POC) analytical microsystems are being developed for use by first responders to allow for rapid, continual monitoring of glucose and lactate via dual responsive amperometric enzyme biosensors, tissue acidosis via impedimetry and VO2 via voltammetry. Minimally invasive multi-analyte monitoring biochips have the potential to explore areas still unexplored in the realm of trauma physiology.